Aging process at mollecular, subcellular, cellular, tissular and systemic levels.
  Genetic and ecological aspects of the aging process
  The role of age and environment factors with regard to the beginning and the evolution of cronical degenerative diseases.
  Premature aging and longevity.
  Biological age assessment criteria.
  On making, perfecting and applying methods of investigation and treatment for aged patients.
  Devising new gero-protective products.

Laboratory for the Evaluation of Biological Age  

	Dr. Rusu Cornelia, cercet. st. princ. I, main biochemiologist Gradinaru, M.D. Daniela - 2nd main scientific researcher, main biochemiologist Parcalabu Raluca, M.D. - 2nd main scientific researcher, primary medic in geriatry and gerontology Dr. Raducanu Ileana - scientific researcher, geriatry & gerontology specialist Morosanu Bogdan, M.D. - scientific researcher, Internal Medicine Specialist Hnidei Anca Rodica, M.D. - scientific researcher, Geriatry & Gerontology specialist Constantin Gianina Ioana - scientific researcher, Chemistry specialist

 Study of biological age assesment criteria (establishing antropometrical biomarkers related to age)
  The role of age and environment factors upon the beginning and the evolution of cronical degenerative diseases.

 Premature aging and longevity studies.
 On making, perfecting and applying methods of investigation and treatment for aged patients.
 Clinical studies for the evaluation of the effects of pharmacy products treatment on aged patients.
 The osteodensimetry cabinet performs activities of research and clinical assistance by determining bone mineral density in order to diagnose and monitor osteoporosis patients.

Laboratory for studies of intermediary metabolism biochemistry and tissular pharmaco-dynamics

	Elena Lupeanu, M.D. - 2nd scientific researcher, main biologist Valuch Anton, M.D.- 2nd scientific researcher, main biochemiologist Borsa Claudia 2nd scientific researcher, main chemist Ionescu Cristina3rd scientific researcher, main biologist Opris Simona- scientific researcher, main biochemiologist

 Oxidative stress biochemistry of the aging process and its pathology
 Interrelations between enzymatic systems and medicine related to oxidative stress
 Exploring fat metabolism; studies on plasmatic lipids, lipoproteins and apolipoproteins and their relation with aging and its patology. ;
 The evaluation of some parameters that indicate biological redox status of pathological processes associated with aging (aterosclerosis, diabete), and of the effects of geroprotective therapy on the cellular balance between pro-oxidants and anti-oxidants
 Pharmacological biochemistry Studies;
 Experimental model making for aging pathology.

Cellular and mollecular biology collective

	Revnic Florea, M.D. - 1st scientific researcher, main biologist Rachita Mariana, M.D. - 2nd main scientific reseearcher, main biologist Turcu Ileana - scientific researcher, pathological anatomy primary medic

 Researches on senescence mechanism at cellular and mollecular level;
 Experimental model making to study cellular mechanisms of "in vitro" cell cultures (primary and cellulary lines);
 Cellular aging biomarkers.\
 Experimental pharmacology researches;
 Experimental researches with regard to mechanisms of geroprotective substances;
 New geroprotective products making;
 Studies concerning cellular and mollecular bases of the aging process at skeletal, cardiac and smooth muscle tissue, and eutrophic substance mecanisms;
 Heart remodelling in cardio-vascular diseases: cardio-vasculary pathology experimental induction;
 Study of induced apoptosis for old mouses;
 Study concerning cellular and mollecular mechanisms within the recovery after ischemic myocard, the use of re-perfused Aslavital in order to reduce free-radical generation;
 Study on the effect of standard physical effort on the neuroendocrinal axis and on physiological and biochemical parameters of heart and skeletal muscles at aged people.

Collective for Immunology

	Andrei Victoria - 2nd scientific researcher, main biologist Pena Catalina, M.D. - 3rd main researcher, primary medic on laboratory medicine Dumitrescu Irina, M.D. - research Assistant, medic

 Researches on immuno-senescence mechanisms;
 Researches on auto-immune process pathology;
 Characterizing and evaluating immunity status in normal and pathological states;
 Research of the correlations between cellular immune response and some aspects specific to the high-age, as: cronic degenerative rheumatism, aterosclerosis, neurologic degenerative diseasese;
 Analyses for patient diagnostic and monitoring:
 -evaluating plasmatic proteins, as: Ig A, Ig M, Ig G, C 3 ', C reactive protein, a 1 -fetoprotein
 -determining rheumatoid factors
 -antistreptolisin "0" titration
 -finding crioglobulins
 -evidencing treponemic VDRL antigenes
 -immuno-enzymatic determining of hormons Free T4 and TSH

Collective for Social Gerontology  

	Andrei Victoria - 2nd scientific researcher, main biologist Pena Catalina, M.D. - 3rd scientific researcher, primary medic of laboratory medicine Dumitrescu Irina, M.D. - research assistant, medic

 Study on premature aging and longevity on a psycho-social approach.
 Study on the interrelation between psycho-socio-economic condition and the aging process.
 Demografic aging proces and its medico-psycho-social and economic consequences:
 Study of Romanian demographic aging process: origins, causes, processes,

- population estimations for interval 1995-2050,
- problems of potential demography,
- aspects of territorial demographic aging,</> - demographic consequences,
- economical consequences,
- social consequences,
- medical consequences,
- comparison between demographic aging process evolutions in countries from Eastern and Western Europe.
- Study on sensorial defficiencies and global functionality of affected aged people; methods of medical, psychologic and social support for these people:
- Finding out prevalent sensorial disorders of aged people;
- Finding out the degree on which sensoriality disorders may affect global functionality of aged people;
- Finding out the needs of medical & social interventions, both curative and preventative, to support aged people who have visual and auditive disorders (especially pointing on secondary and tertiary prevention, as primary prevention limits basically to delaying disorders)

Aspects of health and functionality of nonprofessional people caretakers for aged people

Epidemiological studies on transmissible diseases of aged people (tuberculosis, epidemic hepatitis, etc.)

- Study of aspects of psycho-social adaptation within aging process: third-age distress:
- most specifical events and situations of this age;
- resources, capabilities and abilities to confront stress sources (adaptative resources), specific strategies used in view to reduce disadaptative consequences due to existential happenings;
- adaptative consequences due to the confrontation to stress sources (adaptative styles), disadaptative consequences (main factors that block or disturb optimal adaptative processes, cognitive and emotional distorsions);
- external resources of confrontation (social support as moderator of disadaptative effects).
- Studies on the characteristics of self-image and self-concept of aged people as an adjusting function to prevent and alleviate negative consequences of aging process, and to maximize the efficiency of psycho-social adaptation at second- and third-age.

 Analysis of medical and social assistance of aged people in view to structure proper assistance programs.

Guide and technical support of gerontology and geriatry activities in other institutions, regarding social gerontology, in cooperation with Institute's clinical sections sections.

RESEARCH CONTRACTS

National Research Program VIASAN nr. 341,(2004-2006) The relationship between oxidative stress and cellular immune response along the aging process; evaluation by biochemical and immunologic methods on age-groups; , partnership with The National Institute of Research& Development on Pathology and Biomedical Sciences "Victor Babes" in Bucharest.

Project Director from INGG "Ana Aslan" part Cornelia Rusu, Ph.D. in Biochemistry, 1st scientific researcher

International Prooject of Clinical Researchmulticentric, randomized, double-blind, placebo-controlled to evaluate tolerability, safety and maximum doze of Ladostigile on patients with moderated Alzheimer disease  initiated by Teva Pharmaceuticals (Israel) in cooperation with CARDIOMED-Bucuresti (2005-2006).

National Program Excellency Research (CEEX)(2005-2008):The initiation of an index of referential values for sanguine, immunologic and genotoxic determinations on Romanian population, , partnership with The National Institute of Research& Development on Pathology and Biomedical Sciences "Victor Babes" in Bucharest.

National Program Excellency Research (CEEX)(2005-2008):"Post-thraumati c photophysical therapy methods for children, adults, aged people and sportmen" partnership with University of Medicine and Pharmacy "Carol Davila" Bucharest

Project Director From INGG "Ana Aslan" Doina Tutu-Pata, M.D.

National Program Excellency Research (CEEX)(2006-2008): The Genetics of aging process associated with endocrynal, metabolic and cognitive modifications" partnership with National Institute of Endocrynology "Constantin Parhon" Bucharest.

Project Director from INGG "Ana Aslan" Marcela Covic, M.D.

National Program Excellency Research (CEEX)(2006-2008):The evaluation of methylation metabolism by methyl-donor radical competitive reactions, the expressivity of methylation process metabolytes within neuro-endocrynal pathology. Measures and methods of prevention partnership with The National Research Institute for Nuclear Physics and Engineering "Horia Hulubei" in Bucharest.

Project Director from the part of INGG "Ana Aslan"Ileana Turcu, biologist, 2nd scientific researcher

ANSTI Grant Nr. 6103 (2000-2001) :"Study on apoptosis within cardio-vasculary diseases. Molleculary and cellular aspects studied with regard to cardio-vasculary diseases, partnership with The National Institute of Research and Development on Pathology and Biomedical Sciences "Victor Babes" in Bucharest.

Project Director from the part of INGG "Ana Aslan" Floarea Revnic, 1st scientific researcher

National Research Program VIASAN Nr. 030 (2001-2004):"Pathology of blood figurate elements into cardio-vasculary diseases" , partnership with The National Institute of Research and Development on Pathology and Biomedical Sciences "Victor Babes" in Bucharest.

Project Director from the part of INGG "Ana Aslan"Floarea Revnic, 1st scientific researcher

ANSTI Grant Nr. 6180 (2000-2002) "The variation of DHEA seric level in comparison with estrogenic hormons within the menopause process, and its correlation with aterosclerosis and cognitive function disorders at aged female patients ",